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The increase of plasma TMAO concentration was positively correlated with left ventricular diastolic dysfunction

The proposed mechanism involves maintaining synaptic vesicle integrity, competing for receptor sites, and potentially substituting for depleted neurotransmitters

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Seven more applications are under review

Blinding in the STEP 1 to STEP 4 trials may have been compromised somewhat, however, by the fact that the primary outcome is based on a readily measurable, objective measure (weight loss) that patients can self-monitor, and by the large imbalance in GI AEs, a well-known complication of GLP-1 agonists