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This dual mechanism produces both weight loss and glycemic control through direct appetite reductiona fundamentally different pathway than metformin

doi: 10.3389/fmolb.2024.1440187

A thorough medical history and allergy screening should always be conducted before initiating treatment

AMPK antagonizes mammalian target of rapamycin (mTOR) activity, and its downstream effector, p27, inhibits cyclin-dependent kinase 2 (CDK2), thereby blocking the G1/S transition in the cell cycle, halting cell division, and subsequently inhibiting cellular proliferation [57]

CR-induces metabolic reprogramming, which affects the ISGs, consisting of 37% of the total DEGs