exhaustion from semaglutide nausea and to emotional shifts and social awkwardness, people on GLP-1 medications are sharing the side effects they didn't expect — and rarely see talked about. https://www.buzzfeed.com/victoriavouloumanos/ozempic-wegovy-mounjaro-glp-1 Semaglutide Fatigue: Why It Happens

FDA draft guidance for peptide drugs notes that GLP-1 receptor agonists may delay gastric emptyingan interaction sponsors must monitor during development [FDA.gov]

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L et al

One emerging and still-speculative idea deserves mention: some researchers hypothesize that orally delivered BPC-157 may exert systemic effects partly through the gutbrain axis and local signaling, rather than solely through measurable blood levels

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Early signs are often subtle and activity-dependent

Right now, people who are prescribed GLP-1s have some kind of risk factor for Alzheimers, whether its being overweight, obesity, or type 2 diabetes