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In 2021, the annual sales of the drug surpassed $10 billion for the first time, reaching $10.76 billion

"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

Core Evid

Clinical studies have demonstrated that patients can lose more than 50 pounds within six months, even without altering their existing diet or exercise habits

[44] The Thin Line

Key clinical wins : In 2024, Lilly announced new clinical trial results (e.g., further cardiovascular outcome benefits with tirzepatide), which have bolstered prescriber confidence