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Most episodes occur within the first 2-4 weeks after dose initiation or escalation, and tend to resolve as your body acclimates to the medication

For reference, the pivotal trials enrolled adults with a body mass index of 30 kg/m or greater, or 27 kg/m or greater with at least one weight-related comorbid condition such as treated or untreated dyslipidemia or hypertension

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It is released in response to eating and activates a GLP-1 receptor, which is a class B, G protein-coupled receptor [29]