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The documented research dose is ~2.33 mg of total blend per administration, which for a 70 mg vial reconstituted in 3 mL equals 0.10 mL, or 10 units on a U-100 syringe

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There are several theories behind this that involve a combination of improved muscle oxygenation, endogenous release of opioids via muscle contractions, reduced hyperactivity of the sympathetic system, and improvement in psychosociological factors [12]