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Study findings revealed that once-weekly subcutaneous semaglutide showed the largest estimated effect on body weight and several metabolic markers, identifying the GLP-1 RA as a highly promising intervention for future clinical trials in psychiatric populations, although comparative rankings remain uncertain because the evidence base was small, heterogeneous, and largely indirect

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Peptides like GLP-1 analogs (semaglutide), insulin-sensitizing peptides, and some growth hormonereleasing peptides are investigated