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In the SUSTAIN 6 trial, a two-year, pre-approval cardiovascular outcomes study, semaglutide was associated with a statistically significant increase in the risk of DR complications relative to the placebo [25]

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In the Adipose tissue: GLP-1 increases the triad of lipolysis, free fatty acid synthesisand glucose uptake by adipocytes

These medications also appear to lower blood pressure through mechanisms that are separate from weight loss

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Flexibility: The eating window can vary from day to day, accommodating personal schedules and hunger levels The speaker emphasizes that the flexibility of intermittent fasting is often over looked, and it should not be viewed as a rigid or dogmatic practice