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Taper both peptides simultaneously using the same frequency reduction schedule they work synergistically (CJC amplifies GHRH, Ipamorelin acts as a ghrelin mimetic), so staggered tapering provides no biological advantage and complicates adherence

10.1038/s41586-020-1975-8 Nature 139 Parada VenegasD.De la FuenteM

Muskiet MHA, Tonneijck L, Smits MM, van Baar MJB, Kramer MHH, Hoorn EJ, Joles JA, van Raalte DH

Verifying calculations early prevents this extended issue