The most harmful scenario is having gene variants that reduce glutathione levels and high toxin levels that deplete glutathione
It does so by binding to the harmful compounds and helping flush them out
J Plant Physiol 148:391398 Foyer CH, Lopez-Delgado H, Dat JF, Scott IM (1997) Hydrogen peroxide and glutathione-associated mechanisms of acclimatory stress tolerance and signalling
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Environmental Toxins: Household cleaners, smoke, and air pollution all require glutathione for the detoxification process