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The use of GLP-1 medications has increased rapidly in recent years, with estimates suggesting there are millions of users globally and around 1.6 million in the UK alone, according to University College London

For example, c-MET amplification or activation has been reported as one of the major mechanisms for developing resistance to EGFR tyrosine kinase inhibitor (TKI) treatment in non-small cell lung cancer (NSCLC) patients [8, 12, 13]

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