On April 30, 2026, the FDA proposed formally excluding semaglutide and tirzepatide from the 503B bulk drug substances list, a move that would close the last major large-scale compounding pathway for these medications if finalized
Possible mild side effects include: Irritation at the IV site Lightheadedness if dehydrated Nausea in rare cases Always discuss your health conditions and history with your provider before beginning any therapy treatments
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Dizziness on semaglutide or lightheadedness can reduce physical activity, which reduces calorie burn
However, in individuals with diabetes who are taking other glucose-lowering medications, the risk of hypoglycemia increases
Even when these medications are used in appropriate clinical circumstances, it is important to have a multifaceted lifestyle plan in place when weaning off these medications