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The GLP1R variant rs10305420 is a missense variant in the signal peptide region, and may influence stability of the peptide secondary structure (Extended Data Fig
Emission intensity of the purified sensor protein diluted in 20 mM TBS buffer (pH 7.2) was investigated using Cary eclipse fluorescence spectrophotometer (Agilent, USA)
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In conclusion, as shown in Fig S1, the activation of eNOS by BPC 157 is mediated through multiple regulation processes including the promotion of VEGFR2 activation and endocytosis, the activation of positive regulator AKT, the reduction of the interaction of negative regulator Cav-1 with eNOS
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