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This is especially important for pets that have had their gallbladders removed or suffer from ongoing GI problems

Diabetes 69 , 448464 (2020)

doi: 10.13652/j.spjx.1003.5788.2023.80342 541 GuoXTresserra-RimbauAEstruchRMartnez-GonzlezMAMedina-RemnAFitMet al

doi: 10.1016/j.phymed.2021.153558, 26

Effectiveness loss Subjective but important indicator: Peptide stopped working as well Need higher doses for same effect Complete loss of expected benefits Example: BPC-157 was reducing pain, but suddenly stops helping

These observations indicate that GPR119 activation is associated with a dual mechanism of reducing blood glucose: acting directly through pancreatic -cells to promote GSIS and in the gut via the stimulation of the incretins GLP1 and GIP both of which increase insulin release from the pancreas in response to food intake