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When GH levels rise, the liver and other tissues produce more insulin-like growth factor 1 (IGF-1), which mediates many of GHs effects on muscle, recovery, and metabolism

Experimental Dermatology (2015)

Some report slight water retention as GH levels adjust

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Further investigation is required to examine the role that metabolism-dependent genetic mechanisms play in the development of depression and whether these mechanisms can have effects similar to those of antidepressants