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Although regioselective and efficient conjugation between macromolecules is complex, advances in bioconjugation methods such as click chemistry 10 , tag-based strategies 11 , and enzymatic catalysis 12 have enabled controlled, site-specific, efficient, and stable conjugations

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the grant from the Chinese Institutes for Medical Research (CX23YZ15)

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Acknowledgements The research was supported in part by the National Institutes of Health (R01-GM115622 and R01-CA207701 to J.W., R01-AG045183, R01-AT009050, R21-EB022302 and DP1-DK113644 to M.C.W., R01-GM120033 to M.M.-S., R01-NS100893 to M.X.), the Welch Foundation (Q-1912 to M.C.W.), Cancer Prevention and Research Institute of Texas (CPRIT R1104 to J.W., RP130573 to M.M.-S.), Whitehall Foundation Research Grant (2015-05-54 to M.X.), the Curtis Hankamer Basic Research Fund at Baylor College of Medicine (to M.X.), Caroline DeLuca Scholarship (to M.X.), the United States Department of Agriculture, Agricultural Research Service through Cooperative Agreement Number 58-6250-0-008 (to N.C.), the IDDRC Microscopy Core (P30HD024064 and 1U54 HD083092 Intellectual and Developmental Disabilities Research Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development), the Optical Imaging and Vital Microscopy core, and the Cytometry and Cell Sorting Core at Baylor College of Medicine with funding from the NIH (AI036211, CA125123, and RR024574) and the expert assistance of Joel M

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