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This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits

Currently there are three phenotypes of CPTII deficiency described in literature (Joshi and Zierz, 2020): (1) the lethal neonatal form , characterized by reduced CPTII enzyme activity in multiple organs, reduced carnitine concentration, and increased concentrations of long-chain acylcarnitine and lipids in serum

HF is closely related to cardiometabolic diseases such as diabetes, obesity and chronic kidney disease, and strategies that address most or all these intertwined conditions are desirable

J., Lee, J