upset stomach on tirzepatide Diarrhea (Mounjaro) affects approximately 23–31% of patients and is typically mild to moderate, transient, and most common during dose escalation. , It rarely requires discontinuation Tirzepatide (Mounjaro)

For someone already close to frailty thresholds, a 1 to 2 kg hit to lean mass can dramatically reduce chair-stand time and raise the fall risk, which is why the quality of weight loss becomes extremely important in these patients

doi: 10.1152/physiol.2024.39.S1.292

Semaglutide at 2.4mg produced approximately 17% weight loss over 68 weeks

This gap between how peptides are marketed and how Health Canada classifies them creates real legal and financial exposure for clinics, importers, distributors and supplement brands

Mounjaro is not unique

While sublingual options exist, needle anxiety is often manageable with education and smaller gauges (PlexusDx uses 31-gauge needles)