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The SPE column (Supelco/Sigma-Aldrich, Bellefonte, PA) was activated with 2 mL methanol first and balanced with 2 mL deionized water

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Moreover, after 32 weeks of treatment, CagriSema demonstrated a numerically greater improvement in glycemic control, achieving a 2.2%-point reduction in HbA1c levels, compared to 0.9%-points with cagrilintide and 1.8%-points with semaglutide monotherapy [124]