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Pharmacological Research, 153 , 104660

1998;274(4 Pt 2):R9916

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

Two of them are critical for the cysteinyl t-RNA synthesis and subsequent protein translation, and the other two are critical for the persulfide synthesis

Their diet may not be as good for absorbing B12

To verify the involvement of these metabolites in the above reported anti-HSV-2 activity of lactobacilli, we first investigated the production of H2O2 and lactic acid in the experimental conditions used in the antiviral assay