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Studies have shown that superoxide, hydrogen peroxide, peroxyl radicals, and hydroxyl radicals are the major ROS that react with lipids, nucleic acids, and proteins, and lead to downstream protein inactivation, including enzymes, receptors, and ion channels [28] and contribute to neuroinflammation in TBI [29]

41 Ile 29 , Leu 32 The alanine scanning studies revealed that Ile 29 is critical for receptor binding

Liraglutide attenuates diabetic cardiomyopathy via the ILK/PI3K/AKT/PTEN signaling pathway in rats with streptozotocin-induced type 2 diabetes mellitus

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DPN is classified as a microvascular late complication of diabetes and therefore shares risk factors with other micro- and macrovascular complications (duration of diabetes, glycemic control, age, hypertension, dyslipidemia, smoking and obesity) [11]

The effect is dose-dependent and usually transient