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The following is taken from the section, "How should treatment be given", from the peer-reviewed medical-journal article, "The Many Faces of Cobalamin (Vitamin B12) Deficiency": [Start quote] For parenteral therapy in cases of megaloblastic anemia, it has been advised to administer 1000 mg hydroxocobalamin IM twice weekly for a period of 5 weeks, and the dose is reduced to 1000 mg IM every 2 months thereafter

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There is no single correct answer, as the amount of bac water you add depends on your desired final concentration

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5 Another study looking at lower doses of folate replacement (5mg twice daily) found improvements in social responsiveness score and autism diagnostic observation schedule score even at this lower dose in a 12 week period as compared to placebo