doi: 10.1016/j.jdermsci.2015.08.002 80 Guttman-YasskyELowesMAFuentes-DuculanJZabaLCCardinaleINogralesKEet al
CJC-1295 + Ipamorelin (Growth Hormone Secretagogues) What they do: Stimulate your body to release growth hormone Marketed claims: Anti-aging Muscle growth Fat loss Better sleep Skin improvement The reality: CJC-1295 has reported serious cardiovascular events (FDA flagged this) Ipamorelin is less studied Growth hormone manipulation has known risks (cancer, organ growth) FDA status: Both banned from compounding WADA status: Prohibited (growth hormone-releasing substances) Common in: Anti-aging clinics, bodybuilding communities 4
It transfers hydride ions during redox reactions occurring in glycolysis, the TCA cycle, and oxidative phosphorylation
Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
The result is synergistic -- 2-3x greater GH output than either alone (Bowers et al., 1991)
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