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Samare-Najaf M, Zal F, Safari S (2020) Primary and secondary markers of doxorubicin-induced female infertility and the alleviative properties of quercetin and vitamin E in a rat model

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References Mechanism of Action 1 The activity of GHK-Cu is thought to be multifaceted and includes: GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress

Special Populations and Considerations Postmenopausal Women Postmenopausal women represent the majority of alendronate users

However, the authors of this study also concluded that the high attrition rate due to poor patient compliance and mode of administration indicated the lack of feasibility of this intervention and suggested another view that ALA should be neglected as a future study of potential prevention of CIPN if innovative methods and trial designs can be identified and pursued