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342,343,344 The GLP-1R signaling pathway may also affect the expression of MMP-13 and ADAMTS5, by reducing the signal transduction caused by IL-1, thus decreasing their synthesis

The IR-A isoform, but not the IR-B isoform, can also bind the related growth factor, insulin-like growth factor 2 (IGF-2)

These antioxidants can act by directly scavenging free radicals or by modulating the activity of antioxidant enzymes and altering related signaling pathways to suppress ROS production ( Based on the above situation, Tan et al

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