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Slow titration is the standard mitigation
Genetic predispositions in the GLP1R and GIPR genes can correlate with response variability and should inform dose escalation timelines
The 2024 Lancet Commission on dementia prevention, intervention, and care updated its model to include 14 modifiable risk factors and estimated that roughly 45% of dementia cases may be delayed or reduced if those risks are addressed across the lifespan
Jiang YH, Beaudet AL
432,433 Current guidelines recommend that endoscopic interventions should be considered for patients who have failed conservative management and who have aseptic WON with compression of adjacent organs (e.g., the biliary tract or gastrointestinal tract) or who persist in pain 4 weeks after the onset of AP
The liver fat reduction data from Phase 2 (86% at 12mg) far exceeds what has been reported for other GLP-1 or dual-agonist drugs
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