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Doxycycline can irritate the lining of the esophagus, causing esophagitis

2.12 Immunofluorescence The aorta (5 microns thick) was subjected to antigen retrieval by heating it in 10 mM citrate buffer (pH 6.0) at 95 C for 10 min after decalcification and hydration

Proc Natl Acad Sci USA 76:56065610 Inoue M (2016) Glutathionists in the battlefield of gamma-glutamyl cycle

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Running them together gives researchers two complementary repair signals: more local blood supply, plus more repair cells that can travel to where they are needed