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The combined cost of CagriSema may exceed the cost of retatrutide monotherapy, even though retatrutide requires higher individual doses

Choosing the right pharmacological treatment in these patients remains challenging due to the heterogeneous patient population, patients expectation of the treatment outcome, unavailability of efficacious drugs, and the multifactorial and incompletely understood underlying pathophysiology

AOD 9604 is typically administered as a subcutaneous injection, meaning its injected into the fat layer just under the skin

Li et al., 2021a

however, its selectivity toward GLS1 and failure to inhibit the compensatory effect of GLS2 require in-depth study 14