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BSO definitely causes large rises in 4-HNE (Yan, 2006), but the BSO treated mice are the ones who are resistant to diet-induced obesity

Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/Kainate signaling

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However, they determined that the strength of the evidence for these associations was limited, and some of the studies did not adequately correct for potential confounders such as the severity of depression, hormone levels, and lifestyle factors, among other variables