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Notably, the cardiovascular benefits of semaglutide began to emerge within three months of treatment, before significant weight loss or other cardiometabolic improvements were observed, suggesting that mechanisms beyond weight reduction contribute to the drug's cardioprotective effects [26]
A novel signal emerged for urinary tract infections, appearing in 7.5% to 8.8% of participants on retatrutide versus 5.3% on placebo in TRIUMPH-1, prompting investigators to flag it for further evaluation before regulatory submission
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Most clinical trials studied semaglutide use for 68 weeks, but many people continue treatment indefinitely for weight maintenance
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