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Acute exercise temporarily increases DPP-4 activity (likely evolutionary adaptation to manage incretin hormones during physical stress), but chronic regular exercise appears to reduce baseline DPP-4 expression

The listed cash price for a months supply of Saxenda or Wegovy hovers around $1,300, which presents a cost challenge for payers and patients alike

For studies that were over one year in duration, this increased to 8 kilograms

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