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This pattern aligns with findings from CANVAS [42], CREDENCE [60], and DAPA-CKD [58], in which greater absolute eGFR preservation was noted in participants with higher baseline albuminuria

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Insulin, a small amount of proinsulin (insulin / proinsulin ratio is 5: 1), C-peptide and minor amounts of other substances are then packaged into secretory granules and, after an appropriate signal, fuse with the cytoplasmic membrane and release their contents into the extracelullar fluid

Disc electrophoresis