Contraindications include personal or family history of medullary thyroid carcinoma, MEN-2, prior severe hypersensitivity to GLP-1s, history of pancreatitis, severe gastroparesis, and pregnancy or breastfeeding
And in medical research, even the smallest difference can change the results and make like-for-like comparisons impossible
Below, find out what to know about retatrutide and its potential for helping with weight loss
[DOI] [PubMed] [Google Scholar] 333
Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): data from randomized controlled trials
Retatrutide targets GLP-1, GIP, and glucagon receptors, while tirzepatide targets GLP-1 and GIP only