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Emerging brands like Replenza, Keptropy, and FullWell are marketing GLP-1-supportive supplements via direct-to-consumer channels, with emphasis on glycemic control, lean mass preservation, and post-meal tolerance

GLP-1 and exendin-4 show a similar nM affinity while glucagon, secretin, VIP and GLP-2 have at least a hundred times lower affinity for the GLP-1 receptor

They may be prescribed when a patients needs cannot be met by a commercially available drug or during shortages

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But compounded products are not tested in the same regulated clinical trials

Smoothie King launched a GLP-1 Support Menu featuring smoothies with 20 grams of protein or more and no added sugar