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iii Treatment-regimen estimand represents the efficacy irrespective of adherence to the investigational medicine or introduction of rescue therapy for persistent severe hyperglycemia

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While we have no problem at all with that conclusion, it must not have sat well with either the manufacturer of Vetmedin (which fully financed the study and would expect to sell more, not less, pimobendan, and also heavily funds the ACVIM), or with the primary care, general practice (GP) veterinarians who, prior to the publication of the EPIC Study report, diagnosed heart failure and then prescribed pimobendan on a daily basis using more conventional means without the need for echocardiograms

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[PMC free article: PMC2809786] [PubMed: 19679832] 866

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