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J Clin Endocrinol Metab (2010) 95:2497502.10.1210/jc.2009-2247 48 LuqueRMIbez-CostaANetoLVTaboadaGFHormaechea-AgullaDKasukiLet alTruncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas