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T3 is the active form of the thyroid hormone, whereas T4 is converted into T3 in target tissues (such as the liver and kidney) through deiodination by the deiodinase enzymes

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Third, since conditional Slc7a11 knockout mice were unavailable, our in vivo analysis relied on pharmacologic inhibition of the cystine/glutamate transporter and cannot completely exclude off-target effects of sulfasalazine or the contribution of other cell types beyond dendritic cells and fibroblasts in glutathione synthesis