Schiavi S, Rosa PL, Petrillo S, Carbone E, DAmico J, Piemonte F, Trezza V (2022) N-acetylcysteine mitigates social dysfunction in a rat model of autism normalizing glutathione imbalance and the altered expression of genes related to synaptic function in specific brain areas
The patient recovered with supportive care
Chemical structures of lipoic acid and lipoyllysine residue The figure illustrates the chemical structures of lipoic acid in its oxidized and reduced forms, its two enantiomers ( R - and S -lipoic acid), and its covalent attachment to a lysine residue of the E2 component of the -ketoacid dehydrogenase complex (and the H protein of the glycine cleavage system), forming a lipoyllysine moiety
Interestingly, metals can also act as stimulators of signaling pathways, such as the pathways involving the MAPK/Erk kinases, contributing to the expression of proto-oncogenes and facilitating cellular transformation (Matsuoka & Igisu, 2002)
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