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Animal models, while more physiologically complex, are expensive, ethically constrained, and often poorly predictive of human pathophysiology, contributing to translational failure ( OoC platforms provide a human-relevant alternative by enabling the assessment of drug efficacy, toxicity, and pharmacokinetics under dynamic, physiologically inspired conditions

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With the rapid weight reduction caused by GLP-1 agonists, 25 to 40 % of the loss is lean mass (muscle tissue)