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The second pathway -arrestin signalling via GLP-1R has over the past decade become the subject of intensive research into the mechanism of biased agonism (preference of one intracellular pathway over another by the same ligand)

doi: 10.1097/EDE.0000000000001486

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It is a tripeptide, three amino acids long, bound to a copper ion

In this review, we discuss how these two G-protein coupled receptor (GPCR) ligands may improve L-DOPA-based treatment with minimized side effects or provide alternative nondopaminergic options for patients who would benefit from early treatment

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