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Weight Loss Efficacy and Comparative Effectiveness Superior Performance of Dual-Agonist Therapies The SURMOUNT-5 head-to-head trial represents a landmark study comparing the two leading GLP-1 medications directly ^2

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The evidence behind semaglutide for weight management Semaglutide's weight-management evidence comes largely from the STEP program (semaglutide for weight management, published in The New England Journal of Medicine , 2021)

Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM (2017) Crosstalk between KCNK3-mediated ion current and adrenergic signaling regulates adipose thermogenesis and obesity