10.2174/187152012803833107 Anticancer Agents Med
Ethics declarations Competing interests RS and JPR received research funding for this study from Researched Nutritionals, LLC
In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]
Whereas the total carotenoids exhibited significant positive correlation with total chlorophyll and TOS
If stress and inflammation has caused your glutathione levels to become depleted, you may have a glutathione deficiency
In accordance with these results, Rinaldi et al