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HCV-induced ROS play a significant role in HCV pathogenesis, as Kupffer cell activation contributes to pro-fibrotic cytokine and ROS production, leading to hepatic damage 91,92

Skin rashes, difficulty breathing, or swelling may indicate an allergic response requiring medical attention

Pathological roles of oxidative stress in autoimmune diseases

These modifications significantly extend the peptides half-life and reduce binding affinity to IGF-binding proteins compared to native IGF-1

Statistical significance was assessed using a one-way ANOVA followed by Dunnetts multiple-comparisons adjustments ( c and d ) or two-sided Students t-test ( a , b, h and i )

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