Major metabolites identified are trimethylamine oxide in urine and gamma-butyrobetaine in feces
GLP-1s likely improve those numbers, though the formal trial hasnt been done
The improvement of this functional marker may indicate an important pathway towards new therapeutic strategies that target glutathione dysregulation in schizophrenia
The company also announced new strategic investments from AARP, Harvard Business School Angels, and Shes Independent, plus a follow-on investment from Esplanade Healthtech Ventures
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At the 12-month follow-up : 87.5% of patients reported significant relief defined as 50% reduction in baseline pain scores Mean VAS pain score dropped from 7.2 at baseline to 2.8 at 12 months KOOS (Knee Injury and Osteoarthritis Outcome Score) improved across all subscales: pain, symptoms, activities of daily living, sport/recreation, and quality of life No serious adverse events were reported across the treatment period The durability of the response at 12 months is particularly notable
