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In: Caplan LR, Siesjo BK, Weir B, Welch KM, Reis DJ (eds)

Although a recent clinical trial investigating IMC-A12 and cetuximab in colorectal cancer patients did not show a benefit with IGF-1R inhibition [60], study patients were resistant to prior anti-EGFR therapy and staining for activated AKT, a marker of EGFR and IGF-1R signaling, did not correlate with outcome

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97,98 An early study found GLP-1 receptors were expressed in psoriasis plaques but not in healthy skin and discussed that this could be due to immune infiltration in the plaques, providing a potential rationale for using anti-inflammatory GLP-1 agonists for psoriasis