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In vitro and preclinical studies examine its influence on NAD salvage pathways, energy expenditure mechanisms, and adiposity regulation under controlled experimental conditions

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History of lifestyle-based attempts: Candidates should have already tried to lose weight through diet and exercise without sustained success

Dual agonists that activate both GLP-1 and GIP receptors have been shown to provide more pronounced weight loss, better glycemic control, and better metabolic outcomes compared to GLP-1 RAs alone