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"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: A randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial." The Lancet , 402(10404), 529-544

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For instance, in the head-to-head SURMOUNT-5 trial, the rate of discontinuation due to AEs was numerically lower for Tirzepatide (6.1%) compared to semaglutide 2.4 mg (8.0%), although the study was not powered for a formal statistical comparison of safety outcomes

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