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The seven mammalian sirtuins (SIRT1-7) utilize NAD+ as a cosubstrate to remove acetyl groups from target proteins, generating nicotinamide, acetyl-ADP-ribose, and the deacetylated protein product

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Int Orthop 37(8):15831589 Kaux JF, Bruyere O, Croisier JL, Forthomme B, Le Goff C, Crielaard JM (2015) One-year follow-up of platelet-rich plasma infiltration to treat chronic proximal patellar tendinopathies