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10.1016/S0140-6736(17)32814-3 44

These alterations result in a significantly extended half-lifeup to 120 times longer than native IGF-1due to reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)

10.1038/nrrheum.2016.91 155 VergneSalleP.PouplinS.TrouvinA

Valproate was first used as an anticonvulsant to treat epilepsy but was subsequently discovered to also have mood-stabilising effects [177], which may be related to bipolar disorder and epilepsy sharing features, such as their episodic nature and being risk factors for one another [178]

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The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial