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Excess accumulation of Fe, Cu, and Zn in the AD brain enhances oxidative stress, facilitates A aggregation, and promotes tau hyperphosphorylation (Eisenstein, 2000)

Abbreviations ACMF: Alternating current magnetic force AgNPs: Silver nanoparticles ASGPR: Asialoglycoprotein receptor ASO: Antisense oligonucleotide AuNPs: Gold nanoparticles AuNRs: Gold nanorods ATRAM: Albumin shell functionalized with acidity-triggered rational membrane BALB/c: Albino, immunodeficient laboratory-bred strain of the house mouse BBB: Blood brain barrier Bi 2 S 3 : Bismuth sulfide BODIPY: 4,4-Difluoro-4-bora-3a,4a-diaza- s -indacene BTNPs: Barium titanate nanoparticles CAFs: Cancer associated fibroblasts CB: Cucurbit CEA: Carcinoembryonic antigen CIS: Cisplatin CPT: Camptothecin CRISPR: Clustered regularly interspaced short palindromic repeats Cr-MOFs: Chromium molecular frameworks CS: Chitosan CSCs: Cancer stem cells CT26 cells: Colon carcinoma cell line CTX: Chlortoxin CuO: Copper oxide DHP: 2-Devinyl-2-(1-hexyloxyethyl) pyropheophorbide DiR: 1,1-Dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide DMAEMA: Dimethylaminoethyl methacrylate DNA: Deoxyribonucleic acid DOX: Doxorubicin DPPC: 1,2-Dipalmintoyl-sn-glycero-3-phosphatidylcholine DPPH-2: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine DSPE-PEG: [1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(poly(ethylene glycol))] EGFR: Epidermal growth factor receptor EMF: Electromotive force EpCAM: Epithelial cellular adhesion molecule receptor EPR: Enhanced permeation and retention EU: European Union FA: Folic acid receptors FDA: Food and Drug Administration Fe 2 O 3 : Iron oxide FITC: Fluorescein isothiocyanate GAP: Azobenzene/galactose grafted polymer GSH: Glutathione GOx: Glucose oxidase H460: Non-small cell lung cancer cell lines H 2 O 2 : Hydrogen peroxide HA: Hyaluronic acid HCLR: HA/Haase/CS/liposome/shRNA HCT-116: Human colorectal carcinoma cell line Hep G2 cells: Human liver cancer cell line HER-2: Human epidermal growth factor receptor 2 HPMA: N-(2-hydroxypropyl methyl) acrylamide HSPs: Heat shock proteins H 2 S: Hydrogen sulphide ICG: Indocyanine green IONPs: Iron oxide nanoparticles LMWP: Low molecular weight protamine MCF-7 cells: Epithelial cell line from breast adenocarcinoma MDA-MB-231: Epithelial human breast cancer cell line MDR: Multidrug resistance miRNA: Micro ribonucleic acid MIT: Mitoxantrone MMP: Matrix metalloproteinase MMP-2: Matrix metallopeptidase 2 MMP-9: Matrix metallopeptidase 9 MnO 2 : Manganese dioxide MR: Magnetic resonance MRI: Magnetic resonance imaging MSNs: Mesoporous silica nanoparticles MUC1: Transmembrane glucoprotein mucin 1 NBM: 2-Nitrobenzyl methacrylate NIR: Near infrared NO: Nitric oxide NQO1: NAD(P)H:quinone oxidoreductase 1 O 2 :

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Protein E of Haemophilus influenzae is a ubiquitous highly conserved adhesin

For example, genetic polymorphisms in GSTs, GCL, and selenoprotein genes were shown to influence mercury body burdens among heavy fish consumers (measured as erythrocyte total mercury levels), as well as urine and hair mercury levels among dental professionals

Blood was collected by cardiac puncture for biochemical measurements